Prehospital lactate clearance is associated with reduced mortality in patients with septic shock

Assessment of disease severity in patients with septic shock (SS) is crucial determining optimal level care. In both pre- and in-hospital settings, blood lactate measurement broadly used combination the clinical evaluation as picture alone not sufficient for assessing outcomes. From 15th April 2017 to 2019, SS requiring prehospital mobile Intensive Care Unit intervention (mICU) were prospectively included this observational study. Prehospital clearance was estimated by difference between (time first contact mICU prior any treatment) (at hospital admission) levels divided lactate. Among 185 study, missing six (3%) setting four (2%) at admission, thus 175 (95%) analysed (mean age 70 ± 14 years). Pulmonary, digestive urinary infections probably cause respectively 56%, 22% 10% cases. The 30-day overall mortality 32%. Mean significantly different who died those survived (respectively 0.41 2.50 mmol.l?1 vs 1.65 2.88 mmol.l?1, p = 0.007). Cox regression analysis showed that associated > (HRa [CI95] 0.49 [0.26–0.92], 0.028) < 2.04 [1.08–3.84], 0.028). A increase handled mICU. Further studies will be needed evaluate if or combined scores could affected triage decision-making process patients.